Sanctum Ophidia

Craglorn · base game

A Nedic temple in northern Craglorn that serves as the stronghold of the Celestial Serpent and his Scaled Court. Hard mode is opted into on veteran by desecrating the Scaled Court's sacred banners.

Bosses4

Possessed Mantikora
A mantikora lit green by the Serpent's hold on it. It opens Sanctum Ophidia and is called down using the Nirncrux Altars at the red pool in the first chamber.
Stonebreaker
An armoured troll swollen with nirncrux, pinned in place by a Serpent Fang and a War-Priest until the group frees it. The trial's second boss.
Ozara
A lamia in the Serpent's service, and the third boss of Sanctum Ophidia.
The Serpent
A constellation that fell to Tamriel as a Celestial and set about remaking Nirn. He holds the minds of two of the Guardian Celestials, the Mage and the Warrior, with only the Thief out of his reach.

Most run comp

The exact group makeup most often logged clearing this trial at this difficulty. The lines a subclassed build mixes are not listed.

Tank

Pureclass Templar · Subclassed Necromancer

Healer

Pureclass Templar · Pureclass Warden

DPS

5× Pureclass Arcanist · Pureclass Necromancer · Pureclass Warden · Subclassed Templar

This exact makeup was logged 2 times.

Ranked by how often a build is run, from the top 100 boss-DPS parses per boss. U50 data, as of 4 Aug 2026.

Sets from this trial4

Every set that drops here, with all of its bonuses. Perfected and non-perfected versions share one entry.

Immortal Warrior
Trial · Heavy
- (2 items) Adds 4% Healing Taken
- (3 items) Adds 1206 Maximum Health
- (4 items) Adds 4% Healing Taken
- (5 items) When you take damage while below 35% Health you gain Major Protection for 20 seconds, reducing your damage taken by 10%. This effect can occur once every 20 seconds.
Twice-Fanged Serpent
Trial · Medium
- (2 items) Adds 129 Weapon and Spell Damage
- (3 items) Adds 1487 Offensive Penetration
- (4 items) Adds 657 Critical Chance
- (5 items) Adds 2305 Offensive Penetration, When you deal damage, your Offensive Penetration is increased by 660 for 5 seconds, stacking up to 5 times. This effect can occur once every half second.
Vicious Serpent
Trial · Medium
- (2 items) Adds 657 Critical Chance
- (3 items) Gain Minor Slayer at all times, increasing your damage done to Dungeon, Trial, and Arena Monsters by 5%.
- (4 items) Adds 657 Critical Chance
- (5 items) Adds 129 Weapon and Spell Damage, Reduces the cost of your Stamina abilities by 8%. When an enemy you have recently damaged dies, you restore 2454 Stamina and gain Major Expedition for 8 seconds, increasing your Movement Speed by 30%. These effects can occur once every second.
Wise Mage
Trial · Light
- (2 items) Adds 657 Critical Chance
- (3 items) Adds 657 Critical Chance
- (4 items) Adds 129 Weapon and Spell Damage
- (5 items) Enemies you damage with fully-charged Heavy Attacks are afflicted with Minor Vulnerability for 10 seconds, increasing their damage taken by 5%.