Possessed Mantikora
Sanctum Ophidia
A mantikora lit green by the Serpent's hold on it. It opens Sanctum Ophidia and is called down using the Nirncrux Altars at the red pool in the first chamber.
Popular builds
The builds groups run most often at this boss, one per role. Ranked by how often each is run, not by damage done.
Most popular Tank build
Sorcerer tank with Lucent Echoes
seen 2×
Skills
Perfected Lucent Echoes5 
Powerful Assault5 
Archdruid Devyric2 
Perfected Destructive Impact2 Most popular Healer build
Arcanist healer
seen 4×
Skills
Spell Power Cure5 Perfected Pillager's Profit5 
Ozezan the Inferno2 
Perfected Grand Rejuvenation2 Most popular DPS build
Arcanist DPS
seen 42×Skills
Spattering Disjunction5 
Perfected Slivers of the Null Arca5 
Perfected Merciless Charge2 
Slimecraw1 
Velothi Ur-Mage's Amulet1 Most popular Support build
Nightblade Werewolf
seen 10×Skills
Perfected Slivers of the Null Arca5 
Savage Werewolf5 Perfected Merciless Charge2 
Zaan1
Ranked by how often a build is run, from the top 100 boss-DPS parses per boss. U50 data, as of 4 Aug 2026.